Neoepobin Patched 90%
Paclitaxel (4 mg/kg i.p. on days 1,3,5,7) induced mechanical allodynia (von Frey threshold from 1.8 g to 0.3 g) and reduced intraepidermal nerve fiber density (IENFD) in hind paw skin from 12.4 fibers/mm to 3.1 fibers/mm by day 21.
We demonstrate that overcomes the pharmacokinetic limitations of a promising neuroregenerative Nurr1 agonist. The dissolving microneedle array provides three key advantages: neoepobin patched