To get the TLP250 optocoupler working in Proteus, you typically need to import a third-party library as it is not always included in the default Labcenter database. The "best" way to obtain a proper working model depends on whether you need a basic PCB footprint or a full functional simulation. Best Download Options for TLP250 Third-Party Simulation Libraries
Once you have downloaded the .LIB and .IDX (or .HEX for some modules) files, follow these steps to install them: tlp250 proteus library download best